Search results for "Active state"

showing 5 items of 5 documents

A possible desensitized state conformation of the human α7 nicotinic receptor: A molecular dynamics study

2017

International audience; The determination of the conformational states corresponding to diverse functional roles of ligand gated ion channels is subject of intense investigation with various techniques, from X-rays structure determination to electrophysiology and computational modeling. Even with a certain number of structures becoming recently available, only few major structural features distinguishing conductive open channel from the non conductive resting protein have been highlighted, while high-resolution details are still missing. The characterization of the desensitized conformation(s) is even more complex, and only few specific characteristics have been identified. Furthermore, exp…

0301 basic medicinealpha7 Nicotinic Acetylcholine ReceptorStereochemistryPyridinesBiophysicsMolecular Dynamics SimulationBiochemistry03 medical and health sciencesMolecular dynamicsmedicineHumansHomology modelingnicotinic receptor epibatidine molecular dynamics inactive stateIon channel[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry Molecular Biology/Structural Biology [q-bio.BM]ChemistryProtein StabilityOrganic ChemistryHydrogen BondingBridged Bicyclo Compounds HeterocyclicSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Protein Structure Tertiary[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry Molecular Biology/BiophysicsElectrophysiology030104 developmental biologyNicotinic agonistα7 nicotinic receptorEpibatidineLigand-gated ion channel[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]medicine.drug
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Limitations of concurrently representing objects within view and in visual working memory

2020

AbstractRepresenting visibly present stimuli is as limited in capacity as representing invisible stimuli in visual working memory (WM). In this study, we explored whether concurrently representing stimuli within view affects representing objects in visual WM, and if so, whether this effect is modulated by the storage states (active and silent state) of memory contents? In experiment 1, participants were asked to perform the change-detect task in a simultaneous-representing condition in which WM content and the continuously-visible stimuli in view were simultaneously represented, as well as a baseline condition in which only the representations of visual WM content were maintained. The resul…

AdultMaleVisual perceptionDissociation (neuropsychology)AdolescentShort-term memorylcsh:MedicinehavaitseminenElectroencephalographynäkömuisti050105 experimental psychologyArticleTask (project management)03 medical and health sciencesYoung Adult0302 clinical medicineHuman behaviourmedicineReaction TimeHumans0501 psychology and cognitive sciencesActive statelcsh:ScienceMultidisciplinarymedicine.diagnostic_testWorking memory05 social scienceslcsh:RWorking memoryElectroencephalographytyömuistiNontherapeutic Human ExperimentationMemory Short-TermVisual Perceptionlcsh:QPerceptionFemalePsychologyLimited resources030217 neurology & neurosurgeryärsykkeetPhotic StimulationCognitive psychologyScientific Reports
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Non-uniform displacement and strain between the soleus and gastrocnemius subtendons of rat Achilles tendon

2018

Achilles tendon (AT) comprises of 3 subtendons arising from the soleus (SOL) and the lateral (LG) and medial (MG) heads of the gastrocnemius muscle. While recent human studies show differential displacement within AT, these displacements have not been attributed to specific subtendons. We tested the hypothesis that the SOL and LG subtendons show differential displacement and strain during various combinations of SOL, LG, and MG excitations. Movement of knots, sutured onto SOL and LG subtendons of 12 Wistar rats, was videotaped, while the muscles were stimulated intramuscularly and ankle torque was assessed. When SOL only was stimulated, the plantar flexion torque was the smallest among the …

Male0301 basic medicineanatomyPhysical Therapy Sports Therapy and RehabilitationAchilles TendonPlantar flexion03 medical and health sciencesGastrocnemius muscle0302 clinical medicinemedicineAnimalsOrthopedics and Sports MedicineDisplacement (orthopedic surgery)Active stateRats WistarMuscle Skeletalta315Achilles tendonStrain (chemistry)Human studiesChemistryankle torquedeformation030229 sport sciencesAnatomy3-dimensional modelRatsAchilles tendon030104 developmental biologymedicine.anatomical_structureTorquecalcaneal tendontriceps suraekantajänneAnkle JointAnkle torqueMuscle Contraction
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Corrosion behaviour of sintered Nd(Fe,Al)B magnets

1997

Abstract The effect of 1–6 at% Al additions to a sintered NdFeB magnet on its corrosion behaviour was tested. The additions do not influence the magnet's corrosion behaviour in the active state and cause beneficial effects in the passive state. The Al additions inhibit atmospheric corrosion of the magnets.

Materials scienceAtmospheric corrosionMechanics of MaterialsMechanical EngineeringMagnetMetallurgyMaterials ChemistryMetals and AlloysGeneral ChemistryActive stateBeneficial effectsCorrosionIntermetallics
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Multiband Photometry of the Blazar PKS 0537-441: A Major Active State in December 2004 - March 2005

2005

Multiband VRIJHK photometry of the Blazar PKS 0537-441 obtained with the REM telescope from December 2004 to March 2005 is presented. A major period of activity is found with more than four magnitudes variability in the V filter in 50 days and of 2.5 in 10 days. In intensity and duration the activity is similar to that of 1972 reported by Eggen (1973), but it is much better documented. No clear evidence of variability on time-scale of minutes is found. The spectral energy distribution is roughly described by a power-law, with the weaker state being the softer.

Physicsgalaxies: active; galaxies: BL Lacertae objects: PKS 0537-441galaxies: activeAstrophysics (astro-ph)FOS: Physical sciencesAstronomy and AstrophysicsAstrophysicsUNESCO::ASTRONOMÍA Y ASTROFÍSICAAstrophysicslaw.inventionTelescopePhotometry (astronomy)galaxies: BL Lacertae objects: PKS 0537-441Space and Planetary Sciencelawgalaxies: active ; galaxies: BL Lacertae objects: PKS 0537-441active [galaxies]Spectral energy distributionActive stateBlazarBL Lacertae objects: PKS 0537-441 [galaxies]:ASTRONOMÍA Y ASTROFÍSICA [UNESCO]
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